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KMID : 0356720120280010027
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Journal of the Korean Society of Coloproctology
2012 Volume.28 No. 1 p.27 ~ p.34
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Stromal-cell-derived Factor 1-α Promotes Tumor Progression in Colorectal Cancer
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Park Se-Jun
Ahn Tae-Sung
Cho Sung-Woo
Kim Chang-Jin
Jung Dong-Jun
Son Myoung-Won
Bae Sang-Ho
Shin Eung-Jin
Lee Moon-Soo
Kim Chang-Ho
Baek Moo-Jun
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Abstract
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Purpose: Although stromal-cell-derived factor (SDF)-1α is suggested to be involved in tumorigenicity and tumor angiogenesis, the clinicopathological significance of its expression in colorectal cancers is not fully understood. We examined SDF-1α expression in colorectal cancers and investigated its relationship to clinicopathological features such as tumor staging, lymph-node metastasis, vascular invasion (VI), lymphatic invasion (LI) and neural invasion (NI).
Methods: Specimens of 83 primary colorectal cancers were examined immunohistochemically, and the relationships between clinicopathological features and SDF-1α expression were analyzed. To compare the expressions between the normal colon tissue and colorectal cancer tissues, we performed Western blot analyses.
Results: According to the Western blot analyses, SDF-1α was more highly expressed in colorectal carcinoma tissues than in normal colonic mucosa (20/21). According to the immunohistochemical stain, SDF-1α was associated with nodal status, distant metastasis, tumor staging, VI and LI. SDF-1α expression had a significant prognostic value for overall survival. Kaplan-Meier plots of survival in patients with high SDF-1α showed that high SDF-1α expression was associated with a shorter overall survival. However, no association was found between SDF-1α expression and other pathologic or clinical variables, including age, gender, degree of differentiation, and presence of perineural invasion.
Conclusion: The expression of SDF-1α might be associated with tumor progression in colorectal cancer. Inhibition of SDF-1α could be a therapeutic option in colorectal cancer patients.
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KEYWORD
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Colorectal neoplasms, Survival, Prognostic factor, SDF-1α, Chemokine CXCL12
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